6-(Piperazin-1-yl)pyridine-3-carbonitrile → 6-(4-(3-(5-(2,2,2-Trifluoroacetyl)thiophen-2-yl)benzoyl)piperazin-1-yl)nicotinonitrile

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Reaction Steps

This compound was synthesized from 6-(piperazin-1-yl)nicotinonitrile and 3-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)benzoic acid as described for example 37 step 3 (60 mg, yield 32%). 1H NMR (400 MHz, DMSO-d6) δ 8.52 (d, J=2.1 Hz, 1H), 8.19-8.17 (dd, J=4.0 Hz, J=1.5 Hz, 1H), 8.00-7.89 (m, 4H), 7.64-7.61 (m, 1H), 7.57-7.55 (m, 1H), 6.96-6.94 (t, J=9.2 Hz, 1H), 3.82-3.74 (m, 6H), 3.47 (m, 2H). MS (ESI) m/z: Calculated for C23H17F3N4O2S: 470.10. found: 515.6 (M+HCOOH)−

Provenance & Evidence