1-(5-methoxypyridin-2-yl)piperazine → HCID 53327861, compound

HRID 874981Notes

Reaction equation

HRID 874981 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:8]=1.[F:15][C:16]([F:32])([F:31])[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25](O)=[O:26])[N:18]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:25]([C:24]3[CH:28]=[CH:29][CH:30]=[C:22]([C:19]4[N:18]=[C:17]([C:16]([F:31])([F:15])[F:32])[O:21][N:20]=4)[CH:23]=3)=[O:26])[CH2:11][CH2:10]2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 190324471-(5-methoxypyridin-2-yl)piperazineHCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Product 1

HCID 53327861HCID 53327861, compoundYield 36%

Procedure

This compound was synthesized from 1-(5-methoxypyridin-2-yl)piperazine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (60 mg, yield 36%). 1H NMR (400 MHz, MeOD) δ 8.28-8.25 (m, 1H), 8.21-8.20 (m, 1H), 7.87-7.86 (m, 1H), 7.74-7.72 (m, 2H), 7.32-7.29 (dd, J=9.2 Hz, 3.1 Hz, 1H), 6.89-6.86 (d, J=9.3 Hz, 1H), 3.93 (m, 2H), 3.80 (s, 3H), 3.62 (m, 2H), 3.55 (m, 2H), 3.43 (m, 2H). MS (ESI) m/z: Calculated for C20H18F3N6O3: 433.14. found: 434.0 (M+H)+

Sources & evidence

ORD record
ord-0e432a7863404874a9396526accff203
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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