3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 53327884, compound

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Reaction Steps

This compound was synthesized from 1-(2,3-dihydro-1H-inden-2-yl)piperazine dihydrochloride and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (100 mg, yield 39%). 1H NMR (400 MHz, MeOD) δ 8.27-8.24 (m, 1H), 8.18 (m, 1H), 7.72-7.71 (m, 2H), 7.20-7.16 (m, 2H), 7.14-7.11 (m, 2H), 3.87 (m, 2H), 3.55 (m, 2H), 3.26-3.20 (m, 1H), 3.17-3.12 (m, 2H), 2.93-2.87 (dd, J=15.1 Hz, 8.5 Hz, 2H), 2.73 (m, 2H), 2.60 (m, 2H). MS (ESI) m/z: Calculated for C23H21F3N4O2: 442.16. found: 443.2 (M+H)+

Provenance & Evidence