3-(N-Boc)-(2-aminoethyl)azetidine → benzyl N-[3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]azetidine-1-carboximidoyl]carbamate
Reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH:11]1[CH2:14][NH:13][CH2:12]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(NCC1C[N:26]([C:28](=N)[NH:29][C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])C1)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH:11]1[CH2:12][N:13]([C:28](=[NH:26])[NH:29][C:30]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[O:31])[CH2:14]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
The title compound was prepared from 3-(N-tert-butyloxycarbonylaminoethyl) azetidine according the procedure for 3-(N-tert-butyloxycarbonylaminomethyl)-1-(N-benzyloxycarbon ylamidino) azetidine, in a yield of 0.090 g (34%).
Sources & evidence
- ORD record
- ord-8f3a40523b2f4c598bcdee0f2ca4642e
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723444
Reaction notes
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