1-(2-Pyrimidinyl)piperazine → HCID 53327925, compound

HRID 875015Notes

Reaction equation

HRID 875015 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:13][C:14]([F:30])([F:29])[C:15]1[O:19][N:18]=[C:17]([C:20]2[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=2)[C:23](O)=[O:24])[N:16]=1>>[N:12]1[CH:11]=[CH:10][CH:9]=[N:8][C:7]=1[N:1]1[CH2:6][CH2:5][N:4]([C:23]([C:22]2[CH:26]=[CH:27][CH:28]=[C:20]([C:17]3[N:16]=[C:15]([C:14]([F:29])([F:13])[F:30])[O:19][N:18]=3)[CH:21]=2)=[O:24])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Product 1

HCID 53327925HCID 53327925, compoundYield 33%

Procedure

This compound was synthesized from 2-piperazin-1-yl-pyrimidine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (52 mg, yield 33%). 1H NMR (400 MHz, CDCl3) δ 8.35 (d, J=4.7 Hz, 2H), 8.23-8.21 (m, 2H), 7.68-7.61 (m, 2H), 6.58-6.56 (t, J=4.7 Hz, 1H), 3.97-3.85 (m, 6H), 3.53 (m, 2H). MS (ESI) m/z: Calculated for C18H16F3N6O2: 404.12. found: 405.1 (M+H)+

Sources & evidence

ORD record
ord-358c52042bb946c3a9763b844c085e6f
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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