N-bromobutanimide → HCID 59402828, compound

Participants

Reaction Conditions

Reaction Steps

N-Bromosuccinimide (3.22 g, 18.13 mmol) was added to a solution of 4-(4-fluorophenyl)-2-methylthiazole (3.5 g, 18.13 mmol) in CCl4 (30.0 mL) and the reaction was refluxed at 80° C. overnight. The reaction mixture was then diluted with CH2Cl2, washed with water and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to yield crude 2-(bromomethyl)-4-(4-fluorophenyl)thiazole (5 g), which was carried through without further purification. 1H NMR (400 MHz, DMSO) δ 8.18 (s, 1H), 7.93-8.01 (m, 2H), 7.26-7.31 (m, 2H), 5.07 (s, 2H). MS (ESI) m/z: Calculated for C10H7BrFNS: 272.94. found: 273.9 (M+H)+

Provenance & Evidence