1-(4-Methyl-1,3-thiazol-2-yl)piperazine → (4-(4-Methylthiazol-2-yl)piperazin-1-yl)(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methanone

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Reaction Steps

This compound was synthesized from 4-methyl-2-(piperazin-1-yl)thiazole and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (90 mg, yield 39%) as yellow viscous liquid. 1H NMR (400 MHz, CDCl3) δ 8.23-8.19 (m, 2H), 7.67-7.61 (m, 2H), 6.20 (m, 1H), 3.94 (m, 2H), 3.57 (m, 6H), 2.26 (m, 3H). MS (ESI) m/z: Calculated for C18H16F3N5O2S: 423.10. found: 424.2 (M+H)+.

Provenance & Evidence