3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 53327948, compound

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Reaction Steps

This compound was synthesized from 2-(4-fluorophenyl)-4-(piperazin-1-ylmethyl)thiazole TFA salt and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (26 mg, yield 34%). 1H NMR (400 MHz, CDCl3) δ 8.20-8.17 (m, 2H), 7.95-7.92 (dd, J=8.8 Hz, 5.1 Hz, 2H), 7.64-7.59 (m, 2H), 7.16-7.11 (m, 3H), 3.89 (m, 2H), 3.80 (s, 2H), 3.51 (m, 2H), 2.72 (m, 2H), 2.57 (m, 2H). MS (ESI) m/z: Calculated for C24H19F4N5O2S: 517.12. found: 518.2 (M+H)+

Provenance & Evidence