3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → (4-((2-(4-Fluorophenyl)oxazol-4-yl)methyl)piperazin-1-yl)(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methanone

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Reaction Steps

This compound was synthesized from 2-(4-fluorophenyl)-4-(piperazin-1-ylmethyl)oxazole TFA salt and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (34 mg, yield 14%). 1H NMR (400 MHz, CDCl3) δ 8.19-8.17 (m, 2H), 8.06-8.03 (dd, J=8.7 Hz, 5.1 Hz, 2H), 7.63-7.57 (m, 3H), 7.17-7.12 (t, J=8.7 Hz, 2H), 3.87 (m, 2H), 3.59 (s, 2H), 3.50 (m, 2H), 2.68 (m, 2H), 2.54 (m, 2H). MS (ESI) m/z: Calculated for C24H19F4N6O3: 501.14. found: 502.1 (M+H)+

Provenance & Evidence