Trifluoroacetate → HCID 131732580, compound

HRID 875038Notes

Reaction equation

HRID 875038 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][C@@H:11]2[CH2:13][C@H:8]1[CH2:9][N:10]2C(OC(C)(C)C)=O.[F:21][C:22]([F:27])([F:26])[C:23]([O-:25])=[O:24]>>[OH:25][C:23]([C:22]([F:27])([F:26])[F:21])=[O:24].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][C@@H:11]2[CH2:13][C@H:8]1[CH2:9][NH:10]2

Participants

3

Reactant 2

HCID 84468TrifluoroacetateHCID 67376913HCID 67376913, compound

Product 1

HCID 131732580HCID 131732580, compound

Procedure

This compound was synthesized from (1S,4S)-tert-butyl 5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate as described for example 46 step 4 (50 mg, crude) as trifluoroacetate salt and it was taken as such for the next step. MS (ESI) m/z: Calculated for C10H13N3: 175.11. found: 175.9 (M+H)+

Sources & evidence

ORD record
ord-b2a48e93808640d99e1a8376743b8e41
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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