HCID 66632182, compound → HCID 68296472, compound

HRID 875052Notes

Reaction equation

HRID 875052 reaction equation
I[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4](C(OC(C)(C)C)=O)[C:3]=1C.[OH:19][CH2:20][CH2:21][N:22]1[CH:31]=[C:30](I)[C:29]2[C:24](=[CH:25][N:26]=[CH:27][CH:28]=2)[C:23]1=[O:33]>>[OH:19][CH2:20][CH2:21][N:22]1[CH:31]=[C:30]([C:2]2[C:10]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[NH:4][CH:3]=2)[C:29]2[C:24](=[CH:25][N:26]=[CH:27][CH:28]=2)[C:23]1=[O:33]

Participants

3

Reactant 2

HCID 66632182HCID 66632182, compoundHCID 682964281H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-iodo-2-methyl-, 1,1-dimethylethyl ester

Product 1

HCID 68296472HCID 68296472, compound

Procedure

Analogously to Example 5, tert-butyl 3-iodo-2-methylpyrrolo[2,3-b]pyridine-1-carboxylate is reacted with 2-(2-hydroxyethyl)-4-iodo-2H-2,7-naphthyridin-1-one, giving 2-(2-hydroxyethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2H-2,7-naphthyridin-1-one as colourless solid; MS (ESI): 307 [M+H]+.

Sources & evidence

ORD record
ord-dc307eca41c243b781455e3ef48ff579
Source dataset
uspto-grants-2015_03
Patent number
US08981101B2

Reaction notes

Loading…