反应详情

1.5 g (5 mmol) of 2-(benzylthio)-8-ethoxy-5,6-dihydroquinazoline were dissolved in 50 mL of acetic acid and 3 mL of water. The solution was stirred at refluxing temperature for 4 hours. The solvent was then removed under vacuum, the residue partitioned between dichloromethane and a NaHCO3 saturated solution. The organic layer was dried over anhydrous Na2SO4 and concentrated, giving 1.0 g (74% yield) of the title compound.

1. temperatureat refluxing temperature for 4 hours
2. customThe solvent was then removed under vacuum
3. customthe residue partitioned between dichloromethane
4. dry with materialThe organic layer was dried over anhydrous Na2SO4
5. concentrationconcentrated