反应详情

0.22 g (0.55 mmol) of 1-[2-(benzylthio)-8-oxo-5,6,7,8-tetrahydroquinazolin-7-yl]-2-phenylethane-1,2-dione were dissolved in 6 mL of ethanol and 0.03 g (0.66 mmol) of methyl hydrazine were added. The reaction mixture was maintained under stirring at refluxing temperature for 5 hours. After that time the solvent was removed under reduced pressure, the residue redissolved with dichloromethane and washed with water. The organic layer was dried over Na2SO4 and concentrated, giving 0.16 g of the title compound (70% yield).

1. temperatureThe reaction mixture was maintained
2. temperatureat refluxing temperature for 5 hours
3. customAfter that time the solvent was removed under reduced pressure
4. dissolutionthe residue redissolved with dichloromethane
5. washwashed with water
6. dry with materialThe organic layer was dried over Na2SO4
7. concentrationconcentrated