HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 875139Generated: October 25, 2026
Iodine → 8-Iodo-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide
https://huagongshe.com/reaction/875139
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Isoamyl Nitrite | HCID 8053 | — |
| Reactant | Iodide Ion | HCID 30165 | — |
| Reactant | Ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide | HCID 68936324 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 8-Iodo-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide | HCID 44232945 | — |
Reaction Steps
In a round bottom flask maintained under argon atmosphere, ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide (13.00 g, 45.400 mmol) was dissolved into anhydrous dimethoxyethane (800 mL); cesiun iodide (11.795 g, 45.400 mmol), bisublimated iodine (5.761 g, 22.698 mmol), copper(I) iodide (2.594 g, 13.621 mmol), and iso-amyl nitrite (9.107 mL, 68.100 mmol) were added in that order and the mixture was heated to 70° C. for 22 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08981089B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-46f7ce74a2f94649aaa872207d9922f2 |
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| Source note | uspto-grants-2015_03 |
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