Hydrazine hydrate (1:1) → HCID 86650747, compound

Participants

Reaction Steps

To a solution of 2-{6-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-pyridin-2-yl}-1H-isoindole-1,3(2H)-dione (1.87 g, 4.27 mmol) in tetrahydrofuran (20 mL) was added dropwise hydrazine hydrate (1.04 mL, 21.4 mmol). After stirring at room temperature for 29 h, the reaction mixture was filtered, the insolubles washed with ethyl acetate, and the filtrate concentrated in vacuo. Purification on silica gel afforded 6-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-amine [1.07 g, yield 77%; HPLC/MS: m/z=308 (M+H); log P(HCOOH)=0.29].

Provenance & Evidence