Potassium Iodide → 2-{6-[({[(1,2-dimethyl-1H-imidazol-5-yl)(phenyl)methylene]amino}-oxy)methyl]pyridin-2-yl}-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

To a solution of 1-(1,2-dimethyl-1H-imidazol-5-yl)-N-hydroxy-1-phenylmethanimine (2.29 g, 10.6 mmol) and 2-[6-(bromomethyl)pyridin-2-yl]-1H-isoindole-1,3(2H)-dione (3.71 g, 11.7 mmol) in acetonitrile (100 mL) were added cesium carbonate (7.27 g, 22.3 mmol) and potassium iodide (176 mg, 1.06 mmol). After stirring at room temperature for 31.5 h, the reaction mixture was filtered, the insolubles washed with dichloromethane, and the filtrate concentrated in vacuo. Purification on silica gel afforded 2-{6-[({[(1,2-dimethyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}-1H-isoindole-1,3(2H)-dione [848 mg, yield 16%; HPLC/MS: m/z=452 (M+H); log P(HCOOH)=1.84].

Provenance & Evidence