Hexanoyl chloride → HCID 86650767, compound

Participants

Reaction Steps

To a solution of 6-[({[(1-methyl-1H-1,2,4-triazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-amine (0.151 g, 0.486 mmol, 1 eq.) in 2 ml of DCM was added TEA (0.098 g, 0.973 mmol, 2 eq.) followed by hexanoyl chloride (0.072 g, 0.053mmol, 1.1 eq.). The reaction was stirred 4 h at room temperature and the solvent was evaporated. The crude was purified by chromatography on silica gel to give N-{6-[({[(1-methyl-1H-1,2,4-triazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}hexanamide (0.156 g, 79% yield) as a clear viscous oil.

Provenance & Evidence