Hydrochloric Acid → 2-​Naphthalenamine, 1,​2,​3,​4-​tetrahydro-​5-​methoxy-​N-​propyl-​, hydrochloride (1:1)

Participants

Reaction Conditions

Reaction Steps

Aqueous HCl 37% w:w (1.1 eq) is added dropwise under reflux for ˜5 min into the mixture obtained to precipitate the N-propyl MAT.HCl. The suspension is cooled down to 20° C. (Tramp=−20° C./h). The suspension is post-stirred at 20° C. for minimum 30 min and filtered. The cake is washed twice with EtOAc (2×1 vol.). The wet solid is dried under vacuum at 40° C. giving an off white solid. Yield: 95.0% from (III)

Provenance & Evidence