Toluene → HCID 66842550, compound

Participants

Reaction Steps

Compound of example 27 (200 mg, 0.47 mmol) was dissolved in anhydrous DCM and toluene (1:1) (2 mL) and solution was cooled to −78° C. DIBAL in toluene (1.0 M, 1.4 mL, 1.2 equivalents) was added dropwise at −78° C. and mixture was stirred for 3 hours. Saturated sodium sulphate solution was added and reaction mixture was extracted by DCM (3×50 mL), dried over sodium sulphate and was concentrated to obtain the title compound.

Provenance & Evidence