Aluminium lithium hydride → HCID 42600288, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of compound of example 27 (424 mg, 1 mmol) in THF (20 mL) under stirring to 0° C., under nitrogen, was added LAH (132.8 mg, 3.5 mmol) and stirred at room temperature (25° C.) for 15 hours. The reaction mixture was quenched with water (3×50 mL), stirred for 10-15 minutes and added ethyl acetate (3×100 mL). The separated ethyl acetate layer was dried over sodium sulphate. The product was obtained by concentrating the ethyl acetate portion. It was dried under vacuum. Crude product was washed with petroleum ether which was crystallized using ethyl acetate (2 mL) and petroleum ether (5-6 drops) to obtain the title compound.

Provenance & Evidence