反应详情

温度

22.5 °C

Tapentadol free base (2.1 g) was added to 2-butanone (32 ml), the mixture was heated to reflux and followed by the addition of water (0.22 ml) and trimethylchlorosilane (1.6 ml) at the same temperature and then maintaining for 1 hour. The resulting mass was cooled at 20-25° C. The resulting solid was filtered, the product was washed with pre-cooled 2-butanone (4 ml) and then the solid was dried at 25° C. for 3 hours to produce 1.8 g of tapentadol hydrochloride salt (Purity by HPLC: 97.78%).

1. temperaturethe mixture was heated
2. temperatureto reflux
3. temperaturemaintaining for 1 hour
4. filtrationThe resulting solid was filtered
5. washthe product was washed with pre-cooled 2-butanone (4 ml)
6. customthe solid was dried at 25° C. for 3 hours