反应详情

78 g (111.39 mmol) of ethyl 5-{[2-(2-{[3-chloro-4′-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylate dihydrochloride (Enantiomer 2, Example 80A) were taken up in 1200 ml of THF, 47 ml of triethylamine were added and the mixture was stirred at room temperature for 1 h. The precipitated triethylammonium chloride crystals were then filtered off and washed with THF. The filtrate obtained was evaporated to dryness. The residue was dissolved in ethyl acetate, washed twice with 10% strength aqueous sodium chloride solution, dried over magnesium sulphate, filtered and once more evaporated to dryness. This gave 69 g (111.24 mmol, 99.9% of theory) of the target compound.

1. filtrationThe precipitated triethylammonium chloride crystals were then filtered off
2. washwashed with THF
3. customThe filtrate obtained
4. customwas evaporated to dryness
5. dissolutionThe residue was dissolved in ethyl acetate
6. washwashed twice with 10% strength aqueous sodium chloride solution
7. dry with materialdried over magnesium sulphate
8. filtrationfiltered
9. customonce more evaporated to dryness