Cyclopropanecarboxamide → N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide

HRID 875374Notes

Reaction equation

Cl[C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[CH:9][NH:8][C:7]=12.[CH:11]1([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12]1>>[NH:8]1[C:7]2=[C:2]([NH:16][C:14]([CH:11]3[CH2:13][CH2:12]3)=[O:15])[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[CH:9]1

Participants

Reactant 2

HCID 80376Cyclopropanecarboxamide

HCID 114350487-Chloro-1H-pyrrolo[2,3-c]pyridine

Product 1

HCID 71061452N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamideYield 7.59%

Procedure

N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide (Intermediate 7, yield: 7.59%) was synthesized from 7-chloro-1H-pyrrolo[2,3-c]pyridine using cyclopropanamide.

Sources & evidence

ORD record: ord-680b6ae575284b7fb7f2f1f52f5dd683
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980911B2

Reaction notes

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