反应详情

温度

90 °C

A mixture of 4-methyl-5-nitropyridin-2-amine (5 g, 32 mmol) and acetic anhydride (20 mL) was heated at 90° C. for 4 hours. After cooling the solvent was evaporated under vacuum. The concentrated mass was dissolved in toluene and evaporated under vacuum. The resulting solid was triturated with diethyl ether and filtered to afford N-(4-methyl-5-nitropyridin-2-yl) acetamide (5.5 g, 87%).

1. temperatureAfter cooling the solvent
2. customwas evaporated under vacuum
3. dissolutionThe concentrated mass was dissolved in toluene
4. customevaporated under vacuum
5. customThe resulting solid was triturated with diethyl ether
6. filtrationfiltered