Propionyl chloride → N-(1H-pyrrolo[3,2-c]pyridin-4-yl)propanamide

HRID 875405Notes

Reaction equation

[NH2:1][C:2]1[C:7]2[CH:8]=[CH:9][N:10](C(OCC3C=CC=CC=3)=O)[C:6]=2[CH:5]=[CH:4][N:3]=1.[C:21](Cl)(=[O:24])[CH2:22][CH3:23]>>[NH:10]1[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:1][C:21](=[O:24])[CH2:22][CH3:23])[C:7]=2[CH:8]=[CH:9]1

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 71061834benzyl 4-amino-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Product 1

HCID 86720631N-(1H-pyrrolo[3,2-c]pyridin-4-yl)propanamide

Procedure

N-(1H-pyrrolo[3,2-c]pyridin-4-yl)propanamide (Intermediate 26) was prepared from benzyl 4-amino-1H-pyrrolo[3,2-c]pyridine-1-carboxylate in an analogous manner using propanoyl chloride.

Sources & evidence

ORD record: ord-48e0afa672cc4dab9e835c03a1e111cb
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980911B2

Reaction notes

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