N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide → 3,5-Dichloro-4-({7-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-(2-methoxyethyl)benzamide

HRID 875431Notes

Reaction equation

HRID 875431 reaction equation
[NH:1]1[C:5]2=[C:6]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:16][C:17]1[CH:22]=[C:21]([C:23](=[O:29])[NH:24][CH2:25][CH2:26][O:27][CH3:28])[CH:20]=[C:19]([Cl:30])[C:18]=1[C:31](Cl)=[O:32]>>[Cl:16][C:17]1[CH:22]=[C:21]([CH:20]=[C:19]([Cl:30])[C:18]=1[C:31]([C:3]1[C:4]2[C:5](=[C:6]([NH:10][C:11]([CH:13]3[CH2:14][CH2:15]3)=[O:12])[N:7]=[CH:8][CH:9]=2)[NH:1][CH:2]=1)=[O:32])[C:23]([NH:24][CH2:25][CH2:26][O:27][CH3:28])=[O:29]

Participants

3

Reactant 2

HCID 71061452N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamideHCID 867206362,6-Dichloro-4-(2-methoxyethylcarbamoyl)benzene carbonyl chloride

Product 1

HCID 867206383,5-Dichloro-4-({7-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-(2-methoxyethyl)benzamide

Procedure

3,5-Dichloro-4-({7-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-(2-methoxyethyl)benzamide was prepared analogously using N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropane carboxamide and 2,6-dichloro-4-(2-methoxyethylcarbamoyl)benzene carbonyl chloride (Compound No. 16).

Sources & evidence

ORD record
ord-8857f4109ccd4fe7952209598cdcf64a
Source dataset
uspto-grants-2015_03
Patent number
US08980911B2

Reaction notes

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