2,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride → 3,5-Dichloro-4-({5-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

HRID 875435Notes

Reaction equation

HRID 875435 reaction equation
[NH:1]1[C:5]2=[CH:6][N:7]=[C:8]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:16][C:17]1[CH:22]=[C:21]([C:23](=[O:26])[NH:24][CH3:25])[CH:20]=[C:19]([Cl:27])[C:18]=1[C:28](Cl)=[O:29]>>[Cl:16][C:17]1[CH:22]=[C:21]([CH:20]=[C:19]([Cl:27])[C:18]=1[C:28]([C:3]1[C:4]2[C:5](=[CH:6][N:7]=[C:8]([NH:10][C:11]([CH:13]3[CH2:14][CH2:15]3)=[O:12])[CH:9]=2)[NH:1][CH:2]=1)=[O:29])[C:23]([NH:24][CH3:25])=[O:26]

Participants

3

Reactant 2

HCID 867206232,6-Dichloro-4-(methylcarbamoyl)benzoyl chlorideHCID 86720641N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)cyclopropanecarboxamide

Product 1

HCID 867206433,5-Dichloro-4-({5-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide

Procedure

3,5-Dichloro-4-({5-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[2,3-c]pyridin-3-yl}carbonyl)-N-methylbenzamide was prepared using N-(1H-pyrrolo[2,3-c]pyridin-5-yl)cyclopropane carboxamide and 2,6-dichloro-4-(methylcarbamoyl)benzene carbonyl chloride (Compound No. 20).

Sources & evidence

ORD record
ord-e94e096b6bfe4ad1b3ce5a202be788aa
Source dataset
uspto-grants-2015_03
Patent number
US08980911B2

Reaction notes

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