N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide → N-[3-(4-Cyano-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropane carboxamide

HRID 875446Notes

Reaction equation

HRID 875446 reaction equation
[NH:1]1[C:5]2=[C:6]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[C:16]([C:18]1[CH:26]=[C:25]([F:27])[C:21]([C:22](Cl)=[O:23])=[C:20]([F:28])[CH:19]=1)#[N:17]>>[C:16]([C:18]1[CH:19]=[C:20]([F:28])[C:21]([C:22]([C:3]2[C:4]3[C:5](=[C:6]([NH:10][C:11]([CH:13]4[CH2:14][CH2:15]4)=[O:12])[N:7]=[CH:8][CH:9]=3)[NH:1][CH:2]=2)=[O:23])=[C:25]([F:27])[CH:26]=1)#[N:17]

Participants

3

Reactant 2

HCID 71061452N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamideHCID 867206254-Cyano-2,6-difluorobenzoyl chloride

Product 1

HCID 86720648N-[3-(4-Cyano-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropane carboxamide

Procedure

N-[3-(4-Cyano-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropane carboxamide (Compound No. 51) was prepared from N-(1H-pyrrolo[2,3-c]pyridin-7-yl)cyclopropanecarboxamide and 4-cyano-2,6-difluorobenzoyl chloride.

Sources & evidence

ORD record
ord-40bf3ab4827d429d9639b0b10b47cb76
Source dataset
uspto-grants-2015_03
Patent number
US08980911B2

Reaction notes

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