Triethylamine → HCID 71061873, compound

Participants

Reaction Steps

A solution of (4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(4-bromo-2,6-dichlorophenyl)methanone (40 mg, 0.113 mmol) and triethylamine (0.23 mL, 0.206 mmol) in anhydrous tetrahydrofuran was treated dropwise with cyclopropane carbonyl chloride (0.01 mL, 0.11 mmol) under ice-cooled condition and stirred at room temperature for 1 hour. Ethyl acetate was added and washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous sodium sulphate and concentrated to afford N-[1-(4-bromo-2,6-dichlorobenzoyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]-N-(cyclopropylcarbonyl)cyclopropanecarboxamide.

Provenance & Evidence