HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-(3-(2-Methoxy-ethoxy)-phenyl)-3-hydroxypropionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 3-(2-Methoxyethoxy)benzaldehyde | HCID 6485561 | — |
| Product | 3-(3-(2-Methoxy-ethoxy)-phenyl)-3-hydroxypropionitrile | HCID 67316257 | — |
Reaction Steps
Addition of acetonitrile to 3-(2-methoxy-ethoxy)benzaldehyde gave 3-(3-(2-methoxy-ethoxy)-phenyl)-3-hydroxypropionitrile as yellow oil. Yield (1.4 g, 63%): 1H NMR (400 MHz, CDCl3) δ 7.27-7.32 (m, 1H), 6.95-7.0 (m, 2H), 6.91 (dd, J=8.0, 1.8 Hz, 1H), 5.0 (t, J=6.2 Hz, 1H), 4.12 (t, J=4.8 Hz, 2H), 3.76 (t, J=4.8 Hz, 2H), 3.48 (s, 3H), 2.75 (d, J=6.2 Hz, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08981153B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-7ea91fde8f81460db1c8253eba07aac0 |
| Source note | uspto-grants-2015_03 |