HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclooctanemethanol → 2-(3-(3-(Cyclooctylmethoxy)phenyl)propyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclooctanemethanol | HCID 77196 | — |
| Reactant | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| Product | 2-(3-(3-(Cyclooctylmethoxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67316819 | — |
Reaction Steps
Mitsunobu reaction of phenol 58 with cyclooctane methanol gave 2-(3-(3-(cyclooctylmethoxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.920 g, 65%): 1H NMR (400 MHz, CDCl3) δ 7.80-7.86 (m, 2H), 7.68-7.73 (m, 2H), 7.10-7.13 (m, 1H), 6.72-6.79 (m, 2H), 6.64-6.68 (m, 1H), 3.65 (d, J=6.4 Hz, 2H), 2.64 (t, J=7.6 Hz, 2H), 1.98-2.06 (m, 4H), 1.65-1.78 (m, 7H), 1.56-1.64 (m, 5H), 1.30-1.40 (m, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08981153B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e9a36817b5394367919d867b11829e27 |
| Source note | uspto-grants-2015_03 |