Oxirane, 2-propyl- → 2-(3-(3-(2-Hydroxypentyloxy)phenyl)propyl)isoindoline-1,3-dione

Participants

Role	Name	HCID	Charge
Reactant	Oxirane, 2-propyl-	HCID 13853	—
Reactant	2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione	HCID 58027542	—
Product	2-(3-(3-(2-Hydroxypentyloxy)phenyl)propyl)isoindoline-1,3-dione	HCID 67315987	—

Reaction Steps

Alkylation reaction of phenol 58 with 1,2-epoxypentane gave 2-(3-(3-(2-hydroxypentyloxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.93 g, 73%): 1H NMR (400 MHz, CDCl3) δ 7.74 (d, J=6.0 Hz, 1H), 7.53-7.60 (m, 1H), 7.47-7.52 (m, 1H), 7.40 (d, J=7.6 Hz, 1H), 7.14-7.19 (m, 1H), 6.78-6.83 (m, 2H), 6.73 (d, J=8.2 Hz, 1H), 3.81 (d, J=4.8 Hz, 2H), 3.73-3.79 (m, 1H), 3.18-3.24 (m, 2H), 2.60 (t, J=7.6 Hz, 2H), 1.73-1.81 (m, 2H), 1.30-1.52 (m, 4H), 0.89 (t, J=6.8 Hz, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08981153B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-f3831d7f37734337a8cbcf7f8ad319b5
Source note	uspto-grants-2015_03