HCID 66771697, compound → HCID 86648102, compound

Participants

Reaction Steps

144.2 g (0.60 mol) of 1-menthyl acetoacetate, 98.8 mg (12.0 mmol) of a catalyst [{RuCl((S)—SEGPHOS)}2(μ-Cl)3][NH2Me2] and 75 ml of methanol were put into a 500 ml capacity autoclave and allowed to undergo the reaction at 70° C. for 5.5 hours under a hydrogen pressure of 4 MPa. The thus obtained reaction solution was subjected to evaporation of the solvent and then distilled under a reduced pressure (121° C./170 Pa) to obtain 143.1 g (yield 98.4%) of the (3S)-1-menthyl 3-hydroxybutyrate of interest as a colorless oily substance.

Provenance & Evidence