Thionyl Chloride → HCID 86652125, compound

HRID 876121Notes

Reaction equation

HRID 876121 reaction equation
[C:1]([C:5]1[C:6]([O:35][CH3:36])=[C:7]([CH:24]=[C:25]([N:27]2[CH:32]=[CH:31][C:30](=[O:33])[NH:29][C:28]2=[O:34])[CH:26]=1)/[CH:8]=[CH:9]/[C:10]1[CH:18]=[CH:17][C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:15][C:11]=1[C:12](O)=[O:13])([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:39])=O>>[C:1]([C:5]1[C:6]([O:35][CH3:36])=[C:7]([CH:24]=[C:25]([N:27]2[CH:32]=[CH:31][C:30](=[O:33])[NH:29][C:28]2=[O:34])[CH:26]=1)/[CH:8]=[CH:9]/[C:10]1[CH:18]=[CH:17][C:16]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[CH:15][C:11]=1[C:12]([Cl:39])=[O:13])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 25234654HCID 25234654, compound

Product 1

HCID 86652125HCID 86652125, compound

Procedure

A solution of the product from Example 26 (257 mg, 0.50 mmol) in thionyl chloride (1.5 ml) was heated at 85° C. for 40 min and then concentrated and dried in vacuo to give the title compound as a solid (0.27 g).

Workup

  1. concentrationconcentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-092330bff4c54a15865aceb61ce50508
Source dataset
uspto-grants-2015_03
Patent number
US08986740B2

Reaction notes

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