Ethanolamine → HCID 53261095, compound

Participants

Reaction Conditions

Reaction Steps

78 mg of 6-chloro-N-(4-morpholinophenyl)pyrimidin-4-amine, 33 mg of ethanolamine and 70 mg of DIPEA were dissolved in 2 mL of n-BuOH and the mixture obtained was charged into a microwave vial and the vial obtained was heated to 200° C. for 60 minutes under microwave irradiation. Progress of the reaction was monitored by TLC. Upon termination of the reaction n-BuOH. was evaporated off and the evaporation residue obtained was subjected to crystallization from n-BuOH-EtOH solvent mixture. 2-(6-(4-Morpholinophenylamino)pyrimidin-4-ylamino)ethan-1-ol was obtained in the form of a colorless solid.

Provenance & Evidence