Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 53410282 | HCID 53410282 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 53261246 | HCID 53261246 | 73% |
Reaction Steps
100 mg of 6-chloro-N-(4-methoxyphenyl)pyrimidine-4-amine in the form of a hydrochloride, 44 mg of isopropylamine and 95 mg of DIPEA were dissolved in 1 mL of n-BuOH in a screw cap vial and the vial obtained was heated to 120° C. for 1 hour. Progress of the reaction was monitored by TLC. Upon termination of the reaction n-BuOH was evaporated off and the evaporation residue obtained was subjected to flash column chromatography (PE:EtOAc 1:1). N4-Isopropyl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine was obtained in the form of a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08986994B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-c2c6bad50789431fa0bf44716a0eb34b |
|---|
| Source note | uspto-grants-2015_03 |
|---|
