Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 53410282 | HCID 53410282 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 53261250 | HCID 53261250 | 81% |
Reaction Steps
75 mg of 6-chloro-N-(4-methoxyphenyl)pyrimidine-4-amine in the form of a hydrochloride, 23 mg of butan-1-amine and 90 mg of DIPEA were dissolved in 1 mL of n-BuOH and charged into a microwave vial and the vial obtained was heated to 200° C. for 45 minutes under microwave irradiation. The reaction was monitored by TLC. The crude product was obtained by evaporating n-BuOH. Purification was carried out by column chromatography using EtOAc. N4-Butyl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine in the form of a colorless solid was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08986994B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-3758f496cd3b488aa2c14801cd312a68 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
