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Amantadine Hydrochloride → 6-chloro-N-(1-Adamantyl)pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Amantadine Hydrochloride | HCID 64150 | — |
| 反応物 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 6-chloro-N-(1-Adamantyl)pyrimidin-4-amine | HCID 53486071 | — |
反応手順
200 mg of 4,6-dichloropyrimidine, 252 mg of 1-aminoadamantane hydrochloride and 452 mg of DIPEA were dissolved in 2 mL of i-PrOH and the mixture obtained was charged into a screw cap vial and the vial was kept overnight in a heating block at 90° C. The reaction was monitored by TLC and was completed after 12 hours. The mixture obtained was cooled to r.t., solvent was evaporated and N-adamant-1-yl-6-chloropyrimidin-4-amine was obtained by column chromatography using PE:EtOAc 10:1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08986994B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-228abab036764f349acb295748861d3d |
| 出典メモ | uspto-grants-2015_03 |