HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 6-chloro-N-(1-Adamantyl)pyrimidin-4-amine | HCID 53486071 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine | HCID 70941076 | 65% |
Reaction Steps
100 mg of N-adamant-1-yl-6-chloropyrimidin-4-amine, 56 mg of p-anisidine, 73 mg of Na-butylate, 2.2 mg of Pd(OAc)2 and 12 mg of BINAP were taken in a screw cap vial under agron in 4 mL of dry toluene and the vial was kept in a heating block at 150° C. for 12 hours. The mixture obtained was cooled to r.t. and purification was carried out by column chromatography using PE:EtOAc 2:1. N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08986994B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-c8eea45fbae14fdb81a3532519effe2e |
| Source note | uspto-grants-2015_03 |