Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 86673657 | HCID 86673657 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 53259802 | HCID 53259802 | 67% |
Reaction Steps
75 mg of 6-chloro-N-(4-chlorophenyl)pyrimidin-4-amine hydrochloride, 18 mg of ethanolamine and 87 mg of DIPEA were dissolved in n-BuOH (1 mL) and the mixture obtained was charged into a microwave vial and the vial obtained was heated to 200° C. for 45 minutes under microwave irradiation. The reaction was monitored by TLC. The crude product was obtained by evaporating n-BuOH. Purification was carried out by column chromatography using EtOAc: MeOH 10:1. 2-(6-(4-Chlorophenylamino)pyrimidin-4-ylamino)ethan-1-ol in the form of a colorless solid was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08986994B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-a8f63b5f149b4428bf52d3b4be390956 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
