2-Methoxyethylamine → HCID 53261395, compound

Participants

Reaction Conditions

Reaction Steps

75 mg of 6-chloro-N-(3-chlorophenyl)pyrimidin-4-amine hydrochloride, 30 mg of 2-methoxyethanamine and 88 mg of DIPEA were dissolved in 1 mL of n-BuOH and charged into a microwave vial and the vial obtained was heated to 200° C. for 60 minutes under microwave irradiation. The reaction was monitored by TLC. The crude product was obtained by evaporating n-BuOH. Purification was carried out by column chromatography using EtOAc. N4-(3-Chlorophenyl)-N6-(2-methoxyethyl)pyrimidine-4,6-diamine in the form of a colorless solid was obtained.

Provenance & Evidence