Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 86673659 | HCID 86673659 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 53259310 | HCID 53259310 | 57% |
Reaction Steps
73 mg of 6-chloro-N-(3-nitrophenyl)pyrimidin-4-amine hydrochloride, 23 mg 2-ethanolamine and 81 mg of DIPEA were dissolved in 1 mL of n-BuOH and charged into a microwave vial and the vial obtained was heated to 200° C. for 60 minutes under microwave irradiation. The reaction was monitored by TLC. The crude product was obtained by evaporating n-BuOH. Purification was carried out by column chromatography using EtOAc: MeOH=10:1. 2-(6-(3-Nitrophenylamino)pyrimidin-4-ylamino)ethan-1-ol in the form of a colorless solid was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08986994B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-17d608bfd76b443596a91fc3d8c24353 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
