Ethanolamine → HCID 53259306, compound

Participants

Reaction Steps

100 mg of 2,6-dichloropyrimidine, 82 mg of m-fluoroaniline and 103 mg of DIPEA in 1 mL of n-BuOH were charged into a microwave vial and the vial obtained was kept in a heating block at 120° C. for 4 hours. The reaction was monitored by TLC and was completed in 4 h. The mixture obtained was cooled to r.t., 61 mg ethanolamine and 139 mg of DIPEA were added and the mixture obtained was heated under microwave irradiation for an hour at 200° C. The reaction was finished and crude product was obtained by evaporating n-BuOH. Purification was carried out by column chromatography using EtOAc: MeOH 20:1. 2-(6-(3-Fluorophenylamino)pyrimidin-4-ylamino)ethan-1-ol in the form of a colorless solid was obtained.

Provenance & Evidence