Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 3-Chloro-4-methoxyaniline | HCID 21441 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 53259303 | HCID 53259303 | 51% |
Reaction Steps
100 mg of 4,6-dichloropyrimidine, 106 mg of 3-chloro-4-methoxyaniline and 103 mg of DIPEA were dissolved in 1 mL n-BuOH and the mixture obtained was charged into a microwave vial and the vial obtained was kept overnight in a heating block at 120° C. The reaction was monitored by TLC and was completed after 12 hours. The mixture obtained was cooled to r.t., 61 mg of ethanolamine and 139 mg of were added and the mixture obtained was heated under microwave irradiation for an hour at 200° C. The reaction was finished and crude product was obtained by evaporating n-BuOH. Purification was carried out by column chromatography using EtOAc: MeOH 20:1. 2-(6-(3-Chloro-4-methoxyphenylamino)pyrimidin-4-ylamino)ethan-1-ol in the form of a colorless solid was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08986994B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-a3ed7a1cf0f7404fba1fbb6d8ae9a336 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
