Cyclohexylamine → HCID 53259302, compound

Participants

Reaction Steps

100 mg of 4,6-dichloropyrimidine, 106 mg of 3-chloro-4-methoxyaniline and 103 mg of DIPEA were dissolved in 1 mL n-BuOH and the mixture obtained was charged into a microwave vial and kept overnight in a heating block at 120° C. The reaction was monitored by TLC and was completed after 12 hours. The mixture obtained was cooled to r.t., 100 mg of cyclohexylamine and 139 mg of DIPEA were added and mixture obtained was heated under microwave irradiation for an hour at 200° C. The reaction was finished and pure product was precipitated out from n-BuOH. The precipitate obtained was washed with cold n-BuOH. Pure N4-(3-chloro-4-methoxyphenyl)-N6-cyclohexylpyrimidine-4,6-diamine in the form of a colorless solid was obtained.

Provenance & Evidence