Ethanolamine → HCID 53259296, compound

Participants

Reaction Steps

190 mg of 6-chloro-N-(4-methoxyphenyl)pyridin-2-amine were mixed with 397 mg of ethanolamine and the mixture obtained was heated in a screw cap vial under argon at 150° C. for 3 days. The mixture obtained was cooled to r.t. and 5 mL of EtOAc were added, The mixture obtained was extracted with 5 mL of EtOAc for three times, the phases were separated, the organic phase was dried and from the dry mixture obtained solvent was evaporated off. The evaporation residue obtained was subjected to flash column chromatography (EtOAc:PE 3:1). 2-(6-(4-Methoxyphenylamino)pyridin-2-ylamino)ethan-1-ol was obtained in the form of a brown oil.

Provenance & Evidence