HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Aminophenoxy)benzene → HCID 63587641, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Aminophenoxy)benzene | HCID 8764 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,6-Dichloropyridine | HCID 16989 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 63587641 | HCID 63587641 | 77% |
Reaction Steps
100 mg of 2,6-dichloropyridine, 150 mg of 4-phenoxyaniline, 329 mg of K2CO3, 3 mg of Pd(OAc)2 and 9 mg of BINAP were charged into a microwave vial and 2.5 mL of dry toluene were added. The mixture obtained was treated in the vial analogously to the method as set out in Example 16a. For flash chromatography a solvent mixture of EtOAc:PE=1:10 was used. 6-Chloro-N-(4-phenoxyphenyl)pyridin-2-amine was obtained in the form of yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08986994B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-33a28d60743c47b4ab1aa89b836fd422 |
| Source note | uspto-grants-2015_03 |