5,6,7,8-Tetrahydro-2,6-naphthyridin-1(2H)-one--hydrogen chloride (1/1) → HCID 90413771, compound

HRID 876211Notes

Reaction equation

HRID 876211 reaction equation
Cl.[C:2]1(=[O:12])[C:11]2[CH2:10][CH2:9][NH:8][CH2:7][C:6]=2[CH:5]=[CH:4][NH:3]1>[Pt]=O.C(O)(=O)C>[C:2]1(=[O:12])[CH:11]2[CH:6]([CH2:7][NH:8][CH2:9][CH2:10]2)[CH2:5][CH2:4][NH:3]1

Participants

4

Reactant 1

HCID 457897645,6,7,8-Tetrahydro-2,6-naphthyridin-1(2H)-one--hydrogen chloride (1/1)

Product 1

HCID 90413771HCID 90413771, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

5,6,7,8-tetrahydro-2H-2,6-naphthyridin-1-one hydrochloride (250 mg, 1.339 mmol), platinum oxide (100 mg) and glacial acetic acid (10 mL) are stirred under hydrogen (5 bar) at r.t. for 24 h.

Sources & evidence

ORD record
ord-100e7bf2f70e48b7ab68bbc7e929a7a6
Source dataset
uspto-grants-2015_03
Patent number
US08987249B2

Reaction notes

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