HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 90413778, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | (4-Amino-3-bromophenyl)acetic acid | HCID 20303490 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 90413778 | HCID 90413778 | — |
Reaction Steps
To 2-(4-amino-3-bromo-phenyl)acetic acid (5 g, 21.73 mmol) in methanol (50 mL) and dichlormethane (100 mL) is added at −5° C. trimethylsilyldiazomethane in diethylether 2 mol/L (31.51 mL, 63.03 mmol) dropwise over a period of 30 min. The reaction mixture is allowed to warm up to r.t. and concentrated. The crude product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987249B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-79de351fc1e9405fb5426db625d9bd33 |
| Source note | uspto-grants-2015_03 |