反应详情

温度

-10 °C

Tert-butyl 4-(2-oxoindolin-1-yl)piperidine-1-carboxylate (100 mg, 0.32 mmol) in ACN is cooled down to −10° C., N-bromosuccinimide (56.47 mg, 0.32 mmol) is added and stirred at −10° C. for 2 h. The reaction mixture is diluted with dichlormethane and water. The organic layer is separated, dried and concentrated. The crude product is used for the next step without further purification. Yield 99%, m/z 395 [M+H]+, rt 1.126 min, LC-MS Method Z020_S01.

1. customThe organic layer is separated
2. customdried
3. concentrationconcentrated
4. customThe crude product is used for the next step without further purification
5. customYield 99%, m/z 395 [M+H]+, rt 1.126 min, LC-MS Method Z020_S01